In immunophenotypic principal component analysis, MPAL treated as T-cell acute lymphoblastic leukemia clustered between cases of non-mixed T-cell acute lymphoblastic leukemia and acute myeloid leukemia, while other MPAL cases were included in the respective non-mixed B-cell progenitor acute lymphoblastic leukemia or acute myeloid leukemia clusters.
Results were compared with data from patients with CMLtreated with imatinib or nilotinib and with data from patients suffering from renal and hepatocellular carcinomas (RCC/HCC) treated with sorafenib or sunitinib.
OM cells (n = 12) and fibroblasts (n = 7) of patients with CMLtreated with dasatinib and OM cells of three patients with CMLtreated with bosutinib showed centrosomal alterations (mean, 14%) compared with 16 (10 OM and 6 fibroblasts) controls (mean, 3%).
We examined cells of the oral mucosa (OM) and fibroblasts of patients with chronic myeloid leukemia (CML) treated with dasatinib and bosutinib.
We analyzed the outcome of a series of 19 newly diagnosed patients with acute promyelocytic leukemiatreated with AIDA modified protocol, using mitoxantrone in place of idarubicin.
We analyzed the outcome of a series of newly diagnosed patients with APLtreated at the Hematology Center of the University of Campinas.
The aim of this study was to evaluate the clinical outcome of APL patients treated with a modified AIDA protocol [] in which idarubicin was replaced by mitoxantrone at an equivalent dose (1 mg of idarubicin = 1 mg of mitoxantrone).
The problem of the high mortality rate during induction was recently addressed in a retrospective study of Brazilian APL patients treated in different centers [] and probably was related to a deficient supportive therapy.
Sixty-three percent of chemotherapy courses were given to treatacute myeloid leukaemia, with the rest for acute lymphoblastic leukaemia or aggressive lymphoma.
Giebel S …
,
Labopin M,
Ehninger G,
Beelen D,
Blaise D,
Ganser A,
Bacigalupo A,
Czerw T,
Holowiecki J,
Fagundes EM,
Nowara E,
Frassoni F,
Rocha V, Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation » «
The purpose of this study was to determine the frequency and outcome of AP in children with ALLtreated with L-asp in a tertiary care pediatric hospital.
L-asp is an effective drug to treatALL, the administration of L-asp requires the monitoring of pancreatic toxicity to detect AP and have treatment initiated as early as possible.
PATIENTS AND METHODS Array comparative genomic hybridization (CGH) was performed on genomic DNA extracted from diagnostic lymphoblasts from 47 children with T-ALLtreated on Children's Oncology Group Study P9404 or Dana-Farber Cancer Institute Protocol 00-01.
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